CRAC Channels

CRAC Channels

The calcium ion is a critical second messenger in immune cell types. The distribution and concentration of calcium in these cells encodes modulation of a range of signalling pathways that impact on basic physiological responses such as inflammation, allergic reactions and immune system activation.

The CRAC channel has recently emerged as a very promising therapeutic target for disorders characterised by inappropriate immune cell responses. CRAC channel antagonists could offer new options for the many disorders of the immune system.

Ca2+

The calcium ion is a critical second messenger in immune cell types. The distribution and concentration of calcium in these cells encodes modulation of a range of signalling pathways that impact on basic physiological responses such as inflammation, allergic reactions and immune system activation.

The CRAC channel has recently emerged as a very promising therapeutic target for disorders characterised by inappropriate immune cell responses. CRAC channel antagonists could offer new options for the many disorders of the immune system.

Primary Assay

CRAC channels are present in a variety of immune cells including CD4+ & CD8+ T cells, B cells and mast cells. CRAC antagonists have previously failed in clinical development due to the lack of an appropriate primary assay. To overcome this issue, Calcico have developed a primary assay that allows the selective measure of low-conductance CRAC activity in a high throughput screen format.

This enables the identification of selective CRAC antagonists and development of reliable structure-activity profiles.

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